- Title
- Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation
- Creator
- Prieto-García, Alicia; Castells, Mariana C.; Hansbro, Philip M.; Stevens, Richard L.
- Relation
- Immunology and Allergy Clinics of North America Vol. 34, Issue 2, p. 263-281
- Publisher Link
- http://dx.doi.org/10.1016/j.iac.2014.01.001
- Publisher
- W.B. Saunders
- Resource Type
- journal article
- Date
- 2014
- Description
- Tetramer-forming tryptase (hTryptase-ß) was recently discovered to have a prominent role in preventing the internal accumulation of life-threatening fibrin deposits and fibrin-platelet clots. The anticoagulant activity of hTryptase-ß is an explanation for the presence of hemorrhagic disorders in some patients with anaphylaxis or mastocytosis. The fragments of hFibrinogen formed by the proteolysis of this prominent protein by hTryptase-ß could be used as biomarkers in the blood and/or urine for the identification and monitoring of patients with mast cell-dependent disorders. Recombinant hTryptase-ß has potential to be used in clinical settings where it is desirable to inhibit blood coagulation.
- Subject
- mast cell; hTryptase-β; mMCP-6; mMCP-7; fibrinogen; fibrin thrombin-dependent coagulation; anaphylaxis
- Identifier
- http://hdl.handle.net/1959.13/1304128
- Identifier
- uon:20803
- Identifier
- ISSN:0889-8561
- Language
- eng
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